中国科学院化学研究所

本研究室主要从事有机光化学方面的研究工作：如竹红菌素的光化学和光疗机制的研究，竹红菌素的分离纯化和改性，以及光动力学性能的研究。

承担天然羟基醌类色素与胶体半导体复合体系光化学研究（1998.01—2000.12），高效低毒光疗药物的研制（2002.1-2004.12）等。

“863”有机光谱烧孔材料的研究----有机染料的合成。
“921”任务中885显影套药的剖析，感光材料中特种添加剂的合成。
“863”利用工业有机废水生物制氢，主要负责有机废水中有机物质的鉴定及所产生的气体的组成的分析。
“863”多孔纳米（二氧化硅，二氧化钛）及轻质微/纳米螺旋碳纤维在航空航天器上的应用，主要负责二氧化硅，二氧化钛材料的改性，以及添加到环氧树脂中，对环氧树脂各力学性能影响的研究。

相关专利

1．申请号：98101453.4 公开号：CN1194263A 张曼华，吴韬，翁敏，陈申，沈涛 胺基取代去甲氧基竹红菌素及其制法。
2．International application number: PCT/IBO1/01993 (2001) Manhua Zhang, shangjie Xu, Tao WU, Shen Chen, Tao shen. Aliphatic amino-substituted demethoxylated hypocrellins and their synthesis.

发表论文

1.Tao Wu, Min Weng, Shen Chen, Man Hua Zhang Tao shen . Photovoltaic and electrical properties of Langmuir-Blodgett films incorporating hypocrellins derivatives. J.Photochem. Photobiol.A:Chem.,1998,118,189-195.
2.Tao WU, jiang-quan Shen, chun-hong Tian, ai-min Song, shen Chen,man-hua Zhang, tao Shen. Photoinduced change injecting from excited triplet hypocrellin B into TiO2 colloid in ethanol. Chinese Journal of Chemistry .2000,18,5.770-772.
3.Tao WU, jiang-quan Shen, ai-min Song, shen Chen, man-hua Zhang, tao Shen. Photodynamic action of amino substituted hypocrellins: EPR studies on the photogenrations of active oxygen and f Tao Wu，Shangjie Xu，Jianquan Shen，shen Chen, Manhua Zhang,tao Shen ree radical species. J.of Photochem. Photobiol. B:boil 2000,57,14-21.
4.Tao WU, jiang-quan Shen, shen Chen, man-hua Zhang, tao Shen. EPR Investigation of the Free Radicals Generated during the Photosensitization of TiO2 Colloid by Hypocrellin B. Free Radical Research. 2001, 35,137-143.
5.Aimin Song, Tao Wu ， Shen Chen，Man hua Zhang tao Shen . Synthesis and Photophysical properties of amiphiphilic dyads of flurescein and carbazole linked with a flexible or semi-rigid bridge. Dyes and Pigments ,1998,4,371-382.
6.Tao Wu，Shangjie Xu，Jianquan Shen，Aimin Song，shen Chen, Manhua Zhang,tao Shen. New potential photodynamic therapeutic anti-cancer Agents: synthesis and Characterization of Demethoxy Amino Substituted Hypocrellins. Anti-cancer Drug Design. 2000, 15, 287-293.
7.Tao Wu，Shangjie Xu，Jianquan Shen，shen Chen, Manhua Zhang,tao Shen. Photosensitization of TaO2 colloid by hypocrellin B in ethanol. J. of Photochem. and photobiol. A：Chem，137（2000）191-196.
8.Tao Wu，Jianquan Shen，Aimin Song，shen Chen, Manhua Zhang,tao Shen。Synthesis of demethoxy-amino-substitude hypocrellins: novel photosensitizers for photodynamic therapy. Chinese Chemistry Letter, 2000,11,11；963-966.
9.Tao Wu，Shangjie Xu，Jianquan Shen，shen Chen, Manhua Zhang,tao Shen。 Active oxygen species (1O2, O2 ) generation in the system of TiO2 colloid sensitized by hypocrellin B Submitted to Colloid and Surface. J.Photochem.and Photobiol. B,Biol. 2002, 61, 64-70.
10.Shangjie Xu, Chunhong Tian, Shen Chen, Manhua Zhang. Tao Shen. Photobleaching of Hypocrellin B and its Butylamino-substitured Derivative in Solutions . Photochem, Photobiol. 2001, 74 (2)，184-190.
11.Shangjie Xu, Shen Chen, Manhua Zhang. Tao Shen，Yuande Wu。 Butylamino substituted hypocrellins and photodynamic therapy decreses human cancer in vitro and in vivo. Biochim. Biophys. Acta. 2001, 1537(3), 222-232.
12.Shangjie Xu, Shen Chen, Manhua Zhang. Tao Shen. A novel method for the preparation of amino-substituted hypocrellin B . Bioorg. Med. Lett.,2001, 11, 2045-2047.
13.Shangjie Xu, Shen Chen, Manhua Zhang. Tao Shen，Yuande Wu. Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreses human cancer in vitro. Anti-cancer drug design, 2001, 16 (6),271-277.
14.Shangjie Xu, Jianquan Shen, Shen Chen, Manhua Zhang. Tao Shen. Active oxygen species (1O2, O2 ) generation in the system of TiO2 colloid sensitized by hypocrellin B . J. Photochem. Photobiol. B: Biol, 2002,61,64-70.
15.Shangjie Xu, Shen Chen, Manhua Zhang. Tao Shen. The first synthesis of methylate hypocrellin and its fluorescent excited state cautionary tale. J. Org. Chem. 2003, 68 (5),2048-2050.
16.Shangjie Xu, Xiaoxing Zhang，Shen Chen, Manhua Zhang. Tao Shen. EPR studies of the photodynamic properties of a novel potential photodynamic therapeutic agent : Photogeneration of semiquinoneradical anion and active oxygen species (O2， OH，H2O2 and 1O2). Photochem. Photobiol. Sci. 2003.
17.Chunhong Tian, Shangjie Xu, Shen Chen, Manhua Zhang. Tao Shen. Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activityb of the resulting chelate. Free Radical Research. 2001,35,543-554.
18.Cailan Yu, Shangjie Xu, Shen Chen, Manhua Zhang. Tao Shen. Investigation of photobleaching of hypocrellin B in non-polar organic solvent and Liposome suspension. J. photochem. Photobiol. B: Biol. 2002, 68, 73-78.
19.Huayang Lee, Shen Chen, Manhua Zhang. Tao Shen. Studies on synthesis of two hydrophilic hypocrellin derivatives with enhanced absorptive in the red sprctral region and on generation of O2 and singlet oxygen. J. Photochem. Photobiol. B: Biol, 2003,71,43-50.
20. Huayang Lee, Shen Chen, Manhua Zhang. Tao Shen. The photophysic characteristics of 2-butylamino-2-demethoxyl hypocrellin B. J. Photochem. Photobiol. A:chem2004